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A BLSTM with Attention Network for Predicting Acute Myeloid Leukemia Patient's Prognosis using Comprehensive Clinical Parameters
Abstract
The prognosis management is crucial for highrisk disease like Acute Myeloid Leukemia (AML) in order to support decisions of clinical treatment. However, the challenges of accurate and consistent forecasting lie in the high variability of the disease outcomes and the complexity of the multiple clinical measurements available over the course of the treatment. In order to capture the multi-dimensional and longitudinal aspect of these comprehensive clinical parameters, we utilize an attention-based bi-directional long shortterm memory (Att-BLSTM) network to predict AML patient's survival and relapse. Specifically, we gather a 10-year worth of real patient's clinical data including blood test, medication, HSCT status, and gene mutation information. Our proposed Att-BLSTM framework achieves 77.1% and 67.3% AUC in tasks of predicting the next 2-year mortality and disease relapse with these comprehensive clinical parameters, and our further analysis demonstrates that a next 0 to 3 months prediction performs equally well, i.e., 74.8% and 67% AUC for mortality and relapse respectively.
Figures
An illustration of our framework for mortality and relapse prediction using Att-BLSTM.
An illustration of our framework for mortality and relapse prediction using Att-BLSTM.
Authors
Jeng-Lin Li Chi-Chun Lee
Publication Date
2019/07/23
Conference
EMBC
2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
DOI
10.1109/embc.2019.8856524
Publisher
IEEE